The True Story of the Fugate Family with Blue Skin

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When little Benjamin “Benjy” Stacy was born in 1975 in a small hospital near Hazard, Kentucky, he was the picture of health. He was also very, very blue. So blue, in fact, that his skin was the deep purple color of a plum. His doctors were alarmed by the child’s color, and immediately sent him by ambulance to a hospital in Lexington, Kentucky.

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Little Benjamin was subjected to an enormous variety of tests in an attempt to explain the startling blue color. While he did not appear to be in any distress, doctors began to set up a blood transfusion for the tiny baby. That was when his grandmother decided to speak up: The boy’s father explained that his paternal grandmother Luna was also blue – and apparently was quite healthy in life.

Benjy’s blue color started to fade a bit over the next few weeks, and as he grew the only remaining traces of blue coloration were in his lips and nails – the color was particularly noticeable when he became cold. The doctors came to the conclusion that Benjy had inherited a rare gene found in the Appalachians – a gene which turned entire generations of one family blue.

The First Blue Man in Kentucky

In 1820, Martin Fugate and his wife Elizabeth Smith moved onto the banks of Troublesome Creek, a beautiful area in Appalachian Kentucky. There is no official recording as to whether Martin was actually blue, but he and his wife both carried a recessive gene that would turn their son Zachariah Fugate a startling blue color. Martin and Elizabeth had seven children: four of them were blue. Since the gene causing the blue coloration is recessive, the family had a 25% chance of having a blue child with each pregnancy.

blue2Since the Appalachian region was rural and isolated, inter-marriages occurred. Fugate descendents married other Fugate descendants, concentrating the “blue gene” over the generations.

Luna Fugate, little Benjy’s great-grandmother, was one of the bluest Fugates known to the Appalachian region. Luna was described as being blue all over, with lips the color of a dark bruise. Although blue, she was entirely healthy, and had 13 children in her 84 year span of life.

What Caused the Blue Skin Color?

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The blood on the left has a bluish tinge, due to excess amounts of methemoglobin. The blood on the right is normal. Source: Leah Lefler, 2011

Scientists, of course, were quite intrigued as to the cause of the blue skin tone among the Fugate family. In the 1960’s, a young hematologist named Madison Cawein traveled to the region, with an aim to cure the blue people of their skin color. The doctor hiked through the Appalachian hills, on a mission to find the famous blue people of Kentucky.

He finally found a family willing to participate in her study of the condition, and ruled out any heart or lung condition as the cause of the blue skin. Apart from being blue, the people were entirely healthy.

Dr. Cawein began to suspect a rare condition which causes a blue form of hemoglobin to circulate in the blood. The condition is called methemoglobinemia, which is caused by large circulating amounts of methemoglobin – the methemoglobin is not harmful, but large amounts of the non-functional hemoglobin will tint any tissue containing a blood supply blue.

The first family to volunteer for research, Patrick and Rachel Ritchie, did not want to be blue. Dr. Cawein did several tests to find the cause of the methemoglobinemia, and found the Fugate family was missing an enzyme called diaphorase, an enzyme that converts the methemoglobin back into functional hemoglobin. As the Fugate family’s methemoglobin could not be reconverted into the normal hemoglobin molecule, the blue methemoglobin began to build up and become very obvious in the pale skin of the affected family members.

A Cure for Blue Skin

One way to convert blue methemoglobin back into red hemoglobin is to use a dye called methylene blue. Ironically, a blue dye could change the blue color of the affected blood into a normal red color. Ascorbic acid is another method of treating the condition.

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Methylene Blue: it turns blue people pink. Source: Image Courtesy of Wikimedia Commons

Of course, it was a tad difficult to convince the blue people of Kentucky that a blue dye would cure the condition: Patrick and Rachel volunteered to try the treatment. A simple injection of the dye caused a stunning color change: within minute, Patrick had gone from blue to pink. Having found a way to cure the blue skin color, Dr. Cawein left the people with a supply of methylene blue pills – the pills must be taken on a continual basis, since the body eliminates the dye on a regular basis. Since the dye also tints the urine blue, some of the older mountain people thought the blue color of their skin was literally “pouring” out of them.

As coal trains and other modern highway connectors began connecting Troublesome Creek with the rest of the nation, people began leaving the area. The gene is no longer concentrated, and the chance of intermarriage between two gene carriers is remote. Still, the possibility does exist – as the parents of little Benjy Stacy proved.

The gene found in the Fugate family is from a line of French Huguenots, whose descendants settled into Kentucky, Ireland, and Finland.

The Last Descendants of Blue Skin Family – Benjamin “Benjy” Stacy

article-2105080-11DCC746000005DC-385_634x630The Fugate family tree shows Martin and Elizabeth had a blue boy called Zachariah who married his mother’s sister. Their son named Levy married into a nearby family and they had eight children. One of these children was Luna, who married John Stacy and had 13 children. Ben Stacy comes from this family line, reported ABC News. His mother Hilda Stacy, 56, lives in Hazard, Kentucky. There are other relatives in the Stacy line still alive in Virginia and Arkansas. MailOnline found Mr Stacy has a wife named Katherine Stacy in Alaska and they appear to have four children. Mr. Stacy now works as a water plant supervisor. He gained a wildlife management degree from Eastern Kentucky University.

blue1As eastern Kentucky has become vastly more populated than the early 19th century, and as more genes are married into the Fugate family tree, there were far fewer children born with the condition. The blue people in Kentucky began to disappear in the early 20th century as families moved apart and the disease therefore became less common as inbreeding reduced, reported ABC News.

Looking at the old family portrait, they appear to have been either Photoshopped or made up to mimic characters from children’s cartoon the Smurfs, but science proves that the condition is real.

Source:
Owlcation and Dailymail

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